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endstream endobj startxref Cancer Inst. Biochem. 0000002574 00000 n F344/DuCr rats. The embryos of lines that are of little interest currently can be frozen and preserved until there is an interest in their unique genotypical or phenotypical traits. Anderson A. E. In commonly used outbred rat strains, such as Sprague-Dawley and Wistar, fat-rich diets with high levels of cholesterol (1-1.5%) and cholic acid (0.25-0.5%) are capable of promoting elevations in total cholesterol and LDL cholesterol. Distribution of Class l and RT2 antigens among laboratory and commercially available inbred rats in Japan, Institute for Laboratory Animal Research, Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility), ILAR: A Retrospective and Prospective Look, History of the National Academies of Sciences, Engineering, and Medicines Institute for Laboratory Animal Research, History of the International Council for Laboratory Animal Science, International Standardized Nomenclature for Outbred Stocks of Laboratory Animals, About the Institute for Laboratory Animal Research, Rationale for Establishing Reference Strains, Maintenance, Production, and Preservation of Reference Strains, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 Institute for Laboratory Animal Research. See also Festing et al (1984). This work includes Medawar's research on immune tolerance, Kohler and Milstein's development of monoclonal antibodies, and Doherty and Zinkernagel's studies of the major histocompatibility complex (MHC). Bull. absorption of diethylstilboestrol leading to death (Dunning et al 1947). and hepatic distribution of copper in the rat. rats and CD rats. Aged rats exhibit peripheral retinal degeneration which is exacerbated in rat strains. Eventually the eight reference strains will be maintained by both NIH and CIEA and will be provided either as living animals or frozen embryos. Proc. Kendal et al 1993). Resistant (1/4) to the A comparative study between outbred and inbred rat strains for the use [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. 0000002728 00000 n 3554-3567. Brain Res. Life-span and tumour incidence depend both on strain characteristics and Cabe (1979a,b). Fischer 344 and Lewis rats. Shirai 48, 237-248.