There is no good solution to this problem, which is outside the control of the end users of the animals. This article discusses various approaches toward therapies developed in NHPs that are in the early clinical trial stage in humans. The reviews herein provide detailed information that updates and augments these papers and websites. This type of multi-center approach is often used for clinical studies by the medical community (Llovera and Liesz 2016 and references therein) and by the human genomics community for large-scale investigations of large human disease cohorts, using genome-wide association studies (Manolio 2013, 2017). Northern New England Vascular Societywas founded by Betty LaBombard, Maryann Waters, Anne Musson and Nancy Gardner in 1994 as an Affiliate Chapter of the Society for Vascular Ultrasound (SVU). , Coleman K, Hobbs TR, Lutz C. Van Rompay However, there are always difficulties in quickly securing additional support from funding agencies to increase breeding of any given species, since most funding is already committed to support existing breeding colonies and on-going investigations. Marr, K.B. Language links are at the top of the page across from the title. This issue of the ILAR journal brings together, in one place, articles that discuss the use of NHP models for studying human diseases that are highly prevalent and that cause extraordinary human suffering and financial and social burdens. , Mehra S, Lackner A, Kaushal D. Griffin Neometrics Toolbar 333 Washington St Ste 850, Boston, Massachusetts, 02108, United States, Find your B2B customer within minutes using affordable, accurate contact data from Datanyze. They also discuss early experiments using chimpanzees, which, while unsuccessful in themselves, provided information that was useful for development of the SIV-macaque animal model. Phillips Project R&R is committed to continuing to raise awareness and secure the release of all chimpanzees remaining in U.S. labs into sanctuary. However, although not always attained in practice, NHPs must usually be the animal model that is ultimately employed in the preclinical setting for evaluating efficacy and safety of a pharmaceutical, vaccine, or device prior to human clinical trials. I dedicate this paper to the memory of Dr. Andrew Lackner: scientist, mentor, and great champion of translational research using NHPs. CROs still have the ability to move animals from Asia to the United States. The ability to readily sequence individual animals has prompted the champions of this technology to suggest large-scale sequencing of many more animals, particularly rhesus at the NPRCs (Bimber et al. Robert Lanford and colleagues provide an in-depth review of the history and continuing issues around the use of chimpanzees to ameliorate these three forms of hepatitis, which are caused by three different, unrelated viruses. 2015), and animals with genetically encoded calcium indicators that can be used for imaging neural activity in vivo (Park et al. Please visit Sign Petitions and Send Letters to End Chimpanzee Research to show your support. In summary, advances in NHP genomics have high potential to identify and develop NHP models of use for translational research.
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